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In a published study, oral administration of 350 mg/kg acetaminophen to pregnant rats (0.85 times the MHDD, based on a body surface area comparison) from Gestation Day 13 to 21 (dams) reduced the number of germ cells in the fetal ovary, decreased ovary weight, and reduced the number of pups per litter in F1 females as well as reduced ovary weights in F2 females

Nonetheless, other biological processes such as metabolism [24] and oxidative stress [25] can take part in this crosstalk

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Dose-dependent effects of ethyl pyruvate in mice subjected to mesenteric ischemia and reperfusion