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These enzymes utilize glutathione to conjugate and detoxify drugs and other xenobiotics

J Water Process Eng 65:105789

Cancer 113 (3): 515-21, 2008

Anderson, "Determination of Glutathione and Glutathione Disulfide in Biological Samples", Methods in Enzymol ., 1985 , 113 , 548

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Also, it is evident that aging, altered mitochondrial biogenesis and decreased antioxidant defense capacity along with genetic factors caused insulin resistance which is the major cause of many metabolic diseases