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However, with IBD-current biologic therapies, all these mean some patients primary non-responders, experience a loss of response, intolerance or side effects, defining the urgent unmet need for novel treatments (13, 14)

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Acknowledgements For financial support, this project was supported by the Delaware COBRE program, with a grant from the National Institute of General Medical Sciences-NIGMS P20GM104316-01A1

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