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SHK has also been identified as a mixed and competitive inhibitor of cytochrome P450 enzymes, which may lead to an increased risk of drug interactions and toxicity since these enzymes play a crucial role in drug metabolism (Lupescu et al., 2014)

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RAS mutations reduce the efficacy of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies combined with chemotherapy in metastatic colorectal cancer patients

Abbreviations ACO1, aconitate hydratase 1

Acetaminophen is contraindicated: in patients with known hypersensitivity to acetaminophen or to any of the excipients in the intravenous formulation