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GPX4 at the crossroads of lipid homeostasis and Ferroptosis

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During pyroptosis, GSDMD-N inserts into the cell membrane, forming cytotoxic pores that compromise membrane integrity and facilitate the release of inflammatory mediators (32)

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Materials and methods Animals Adult (810weekold), male C57BL/6 mice (Jackson Laboratories, Bar Harbor, ME) weighing between 20 and 25 g were used

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