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Activation of ER reduces islet excess de novo synthesis of fatty acids and lipogenesis and accumulation of toxic lipid intermediates (299301)
The primary factor contributing to Wilson disease is a mutation in the ATP7B gene, a crucial copper transport protein responsible for biliary copper excretion [122]
Frisch RE
7,77 Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a common complication in which one or more of the following occur due to the loss of proper regulation by the kidneys: Abnormal bone mineralization, strength, growth, and turnover Calcification of non-bone tissues, including blood vessels Irregularities in vitamin D, calcium, phosphorus, fibroblast growth factor-23, and parathyroid hormone metabolism Each of these abnormalities is associated with a high risk of mortality, primarily attributable to the cardiovascular consequences
D.DingH.LawW.-C.YongK.-T.et al (2011)
For example, a recent epidemiological study by Argentieri et al
