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Persistent activation and accumulation of myofibroblasts without resolution of the reparative response underlies the progressive nature of fibrotic reactions in injured tissue [5]

Metabotropic glutamate receptor involvement in the pathophysiology of amyotrophic lateral sclerosis: new potential drug targets for therapeutic applications

This causes profound morphological changes and impairs glucose-stimulated insulin secretion by pancreatic beta cells, resulting in aberrant glycometabolic control, contributing to acute and long-term health complications 136,139,140

Moreover, lipid ROS triggers ferroptosis in some cell lines by activating the mitogen-activated protein kinase pathway (Yu et al., 2015

Sci Signal (2015) 8(396):ra97

Kinetics and mechanisms of hypochlorous acid reactions