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IRS-1 is localized in the cytoplasm or nucleus, while IRS-2 is excluded from the nucleus and is exclusively expressed in the cytoplasm or at the plasma membrane [90]

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8, the release of Dox was superficial upto 48 h of time of incubation at pH 7.4 due to neutral pH environment base surrounding, but remarkable Dox release trend was noticed in acidic environment (pH 5.5, and 6.5)

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