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about 50% of newly diagnosed cases of pernicious anemia have detectable antithyroid antibodies

2011;127(3):773-86.e1

the enzyme's activity responds to sustained suppression over days and weeks, not single-dose precision
[7] Mechanisms of Action Liothyronine is an L-isomer that binds with high affinity to nuclear thyroid hormone receptors (TR1, TR1, TR2) distributed across nearly every tissue

Patients must be counseled on these risks, and prescribers should document informed consent

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