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Similar to the metabolism of VLDL, chylomicrons are metabolized in the circulation through the hydrolysis of triglycerides by LPL and hepatic lipase to form cholesteryl ester-enriched chylomicron remnants, which release free fatty acids that can be used for energy by the tissues

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PT-141 is a lactam analog

The mechanism of FAO in cancer drug resistance and potential therapeutic targets to inhibit FAO are then considered and, finally, we summarize the current potential and status of FAO targeting to treat tumors