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GHK-Cu upregulates genes involved in collagen synthesis, extracellular matrix assembly, and tissue remodeling while downregulating genes associated with tissue destruction (matrix metalloproteinases, inflammatory cytokines)

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As a result, the balance between cell proliferation and apoptosis is disrupted, contributing to gastric carcinogenesis ( waf1/cip1 , proapoptotic protein Bax-1 and cleaved caspase 3 but also reversed the increase in the cell proliferation markers including cyclin D1 and PCNA, suggesting that lycopene protects the gastric mucosa from smoking-induced damage through p53-dependent cell cycle control and apoptosis, and may counteract the development of gastric cancer associated with smoking (Figure 3)

doi: 10.3390/brainsci8060109

Upon delivery, it was reported that the peptide appeared to induce a slight increment in levels of blood glucose and lactate, with a slight reduction in the ratio of glycogen synthase in muscle, adipose tissues, and the liver
