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[4] Based on animal research, it is thought that the increased methylmalonyl-CoA hydrolyzes to form methylmalonate (methylmalonic acid), a neurotoxic dicarboxylic acid, causing neurological deterioration

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Characteristics of an Injection Flare: Significant fluid accumulation in the joint Substantial swelling and pain Symptoms appearing within 4 hours to several days after injection More intense than expected post-injection discomfort If you develop an injection flare, contact your healthcare provider

40,41 The magnitude of these reductions can be as large as 76% and 75%, respectively, compared to levels in healthy volunteers with renal clearance of thiamine increased 16-fold in T2DM patients

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