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Research Summary Dihexa is a small peptide angiotensin IV derivative shown in preclinical studies primarily using rodent models to significantly enhance synaptogenesis, cognitive function, and neuroprotection by activating the HGF/c-Met pathway

Yang K, Liu Q, Liu Z, Du S

No recovery was seen following a drug-free period

Stable Gastric Pentadecapeptide BPC 157 as a Therapy and Safety Key: A Special Beneficial Pleiotropic Effect Controlling and Modulating Angiogenesis and the NO-System, Sikiric P, Seiwerth S, Skrtic A, Staresinic M, Strbe S, Vuksic A, Sikiric S, Bekic D, Soldo D, Grizelj B, Novosel L, Beketic Oreskovic L, Oreskovic I, Stupnisek M, Boban Blagaic A, Dobric I, Pharmaceuticals (Basel), Pharmaceuticals, 2025 Jun 19;18(6):928

Freezing causes ice crystal formation that mechanically disrupts the peptide structure