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Serious adverse events are rare

Population studies indicate increased systemic oxidative stress biomarkers in hypertensive patients, correlating oxidative stress with a higher risk of hypertension even in normotensive individuals [247]

"Increased Concentrations of Homocysteine in the Cerebrospinal Fluid in Patients with Fibromyalgia and Chronic Fatigue Syndrome"

All these aspects are essential to the processes of accumulation and metabolism of this element in the human body