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Description
In rats, it caused liver cancer (hepatocellular carcinoma) and benign and malignant tumors of the esophagus (papilloma and carcinoma) following administration in the drinking water or subcutaneous injection (IARC 1978e)
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doi: 10.1211/jpp.57.11.0017
On the one hand, high expression of EC-SOD inhibited the increase in methylase activity and downregulated the expression of recombinant DNA methyltransferase 1(DNMT1) and DNMT-3b, thereby inhibiting the increase in HIF1 and biological oxidants
Evidence that the plant cannabinoid cannabigerol is a highly potent alpha2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist
