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This means a lower and less predictable amount of the active compound might reach systemic circulation, potentially requiring higher doses and introducing variability into research findings

After ingestion, stomach acid separates B12 from food proteins, and then intrinsic factor produced in the stomach lining binds to B12 so it can be absorbed in the ileum (the final section of the small intestine)

The intrinsic factor then binds with B12, facilitating the uptake of B12 in the small intestines.[ref] Without intrinsic factor, you cant absorb B12 from animal proteins

Fat-soluble hormones work by entering your cells and diffusing across the plasma membranes to bind with your DNA

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