ghk-cu copper toxicity risks Molecular Medicine Reports Copper toxicity.pdf

Johnson WM, Wilson-Delfosse AL, Mieyal JJ

This tumor-protective gene signature earned GHK-Cu selection by the Broad Institute Connectivity Map as the best agent among 1,309 bioactive molecules for reversing metastatic colon cancer gene signatures

doi: 10.1095/biolreprod63.5.1285 69 WangJWangWLiSHanYZhangPMengGet al

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Grahame Hardie, 2016)

The lack of central carbon and nitrogen catabolism not only leads to energy deficiency but also reduces the supply of the main metabolite anabolic precursors such as pyruvate, acetyl-CoA, glucose-6-phosphate, and erythrose 4-phosphate used for biomass biosynthesis 21