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The simultaneous reduction in pro-inflammatory cytokines and increase in anti-inflammatory IL-10 also addresses the neuroinflammatory component that many researchers now believe drives Alzheimer progression as much as amyloid itself
One-Year Randomized Trial of Lorcaserin for Weight Loss in Obese and Overweight Adults: The BLOSSOM Trial
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If anyone in your blood family has an autoimmune condition it's more likely (but not definite) that you could develop one also (this includes the Hashimtos thyroiditis that Marz has previously mentioned)
Both conditions, if left untreated, can cause neuropathy, which is damage to the nervous system