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PON1 , an enzyme that circulates in the blood attached to HDL cholesterol, metabolizes homocysteine-thiolactone back to homocysteine in the bloodstream

J Thorac Cardiovasc Surg 162(1):259-268.e4, 2021

Pyruvate/lactate and acetoacetate/beta-hydroxybutyrate are indicators of the cytoplasmic and mitochondrial [NAD + ]/[NADH], respectively, while the malate/pyruvate and isocitrate/alpha-ketoglutarate are indicators of the cytoplasmic [NADPH]/[NADP + ]

[DOI] [PMC free article] [PubMed] [Google Scholar] 191.Bourgeais J., Ishac N., Medrzycki M., Brachet-Botineau M., Desbourdes L., Gouilleux-Gruart V., Pecnard E., Rouleux-Bonnin F., Gyan E., Domenech J., Mazurier F., Moriggl R., Bunting K.D., Herault O., Gouilleux F

GSSG is a product of the oxidation of GSH, which has no biological activity and needs to be reduced to GSH by consuming energy under the action of enzymes in order to resume its function