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Kirkpatrick and Harein (1965) reported a 75% reduction in emerging Indian-meal moth adults following exposure to 120- to 2,000-Hz sound during 4 days of the larval stage
In addition, the PPA model demonstrated that pentoxifylline intervention resulted in augmented neuronal density in CA1 and CA3 of the hippocampus, elevated Purkinje cell numbers, and diminished GFAP immunoreactivity and IL-17 and TNF- levels in the brain [96]
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This approach could allow precision-targeting of PD subtypes with mitochondrial dysfunction, as well as monitoring of LRRK2 inhibition in trials
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