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doi: 10.1155/2022/4970973 120 RoelfsemaJHWhiteSJAriyrekYBartholdiDNiedristDPapadiaFet al

[152:57] Andrew Huberman What's a standard dose

For people with malabsorption or pernicious anemia, injections are medically necessary

While radiological and upper motor neuron findings can support the diagnosis, overdependence on these features may postpone necessary intervention

Maintenance dosing considerations Not everyone needs or tolerates the 12mg maximum dose

Butyrate optimizes mitochondrial function, with effects that involve an increase in mitochondria-located sirtuins-3, which deacetylates and disinhibits the pyruvate dehydrogenase complex (PDC), leading to an increase in the conversion of pyruvate to acetyl-CoA, which increases ATP production by the tricarboxylic acid (TCA) cycle and oxidative phosphorylation [208]