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In PD, HO-1 was measured to be increased in nigral astrocytes and in neuronal Lewy bodies (Schipper et al., 2019)
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doi: 10.1016/j.jstrokecerebrovasdis.2016.04.014, 173
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Therefore, inhibiting SLC7A11 can interfere with the synthesis of glutathione in tumor cells and disrupt the oxidative-reductive homeostasis of cancer cells (Bhutia et al., 2015
