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Other small compounds are also described as ferroptosis inducers, including two FDA-approved drugs, sulfasalazine, prescribed for lung carcinoma and fibrosarcoma (50, 51) and sorafenib (52)

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However, there is also evidence that KEAP1 is not only restricted to the cytoplasm but can undergo nuclear-cytoplasmic shuttling

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Bhatt DL, Steg PG, Brinton EA, Jacobson TA, Miller M, Tardif JC, Ketchum SB, Doyle RT Jr, Murphy SA, Soni PN, Braeckman RA, Juliano RA, Ballantyne CM

Below, we address one of the frequently encountered problems in GST-tagged protein purificationinefficient elution of GST-tagged proteinsby providing an analysis and solutions