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Studies using simulated gastric fluid have shown structural integrity preserved at pH levels as low as 1.5, attributed to its proline-rich sequence resistant to pepsin cleavage

J Chromatogr B Biomed Sci Appl 713(1):111135 Kim SK, Novak RF (2007) The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression

Hypoxia-inducible factors (HIFs), composed of an oxygen-sensitive subunit and a constitutively expressed subunit, act as master regulators that enable cells to sense and respond to changes in oxygen availability (71)

Pernicious anemia is an autoimmune disease that attacks and potentially destroys gut cells so that intrinsic factor is not present, which is crucial for vitamin B12 to be absorbed

doi: 10.1016/j.bbabio.2010.04.018

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