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Limitations of current knowledge: The majority of mechanistic and efficacy data derive from in vitro studies and animal models

Likewise, there is the recovery of disabled smooth muscle functioning (various sphincter function recovery [86,92,93,94,95,96,97,98,99], adaptation following intestine resection, and healing following anastomosis creation [103,104])

Coverage policies vary by Medicare Administrative Contractor region and may include frequency limits or prior authorization requirements for chronic pain indications