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Quantitative phosphoproteomic analysis reveals unique cAMP signaling pools emanating from AC2 and AC6 in human airway smooth muscle cells

Ramnarine SI, Haddad EB, Khawaja AM, Mak JC, Rogers DF

Enzymes that play a crucial role in protecting cells against ROS include glutathione peroxidase, which facilitates the reduction of hydrogen peroxide and organic peroxides, superoxide dismutase (SOD), which helps in the conversion of superoxide radicals into hydrogen peroxide, and catalase (CAT), which helps in maintaining optimal levels of hydrogen peroxide within cells by neutralizing it

(A) Molecular structure of glutathione, (B) the extended, and (C) the folded conformations

Quercetin achieves this through its iron-chelating capabilities, particularly via its B ring catechol, which significantly reduces hydroxyl radical formation from metal-catalyzed reactions

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