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Long-term opioid use often leads to Opioid Induced Hyperalgesia a condition where the nervous system becomes more sensitive to all stimuli
[DOI] [PubMed] [Google Scholar] 392.Horn J.R., Hansten P.D., Chan L.-N

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Concomitantly, as shown in animal models of catabolic stress, glutamine-using tissues including the gut, kidney, and immune cells markedly increase their uptake and metabolism of glutamine (1, 6, 7, 9, 11, 14, 15, 16, 46)

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Boyce, M
