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No human safety data : The complete absence of human clinical trials means the safety profile, side effects, optimal dosing, and pharmacokinetics in humans are entirely unknown Animal-to-human translation is uncertain : Metabolic differences between mice and humans mean that the magnitude of effects (e.g., weight loss, grip strength improvement) may not translate

doi: 10.1016/j.metabol.2021.154886 118 SkjaerbaekCFrystykJOrskovHKissmeyer-NielsenPJensenMBLaurbergSet al

Moreover, sagittal imbalance, reflected by increased SVA, shifts the bodys center of gravity anteriorly, increasing the load on the anterior column and contributing to disc degeneration 35,36

For example, eliminating gluten and casein from the diet has been shown to improve symptoms in children with autism (9)

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However, the specific metabolic checkpoints of the altered thresholds need further exploration, which is a future research direction