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Thats why the GHIGF-1 axis is the key mechanism

For example, butyrate can not only inhibit the NF-B signaling pathway and reduce pro-inflammatory cytokine secretion but also exert anti-inflammatory and regulatory effects by modulating receptors such as GPR43, GPR41, and GPR109A (190)

J Trace Elem Med Biol 21:4043

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Studies have shown that the excess iron overload could result in ferroptosis by accumulating ROS through the Fenton reaction

Increased trimethylamine N-oxide is not associated with oxidative stress markers in healthy aged women