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During stressful conditions, such as MTX-induced oxidative damage, unresolved ER stress leads to the accumulation of unfolded proteins promoting apoptosis (Teske et al., 2011)

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Lipid peroxidation, the executioner of ferroptosis, holds an undeniable role in the pathogenesis of BD

SR101 (red) applied transcranially 3 h after injury diffused more heavily into the brain parenchyma of CBX-treated mice when compared to the vehicle control group

It requires the consecutive activity of the enzymes gamma-glutamylcysteine synthetase (GCS) and glutathione synthetase (GSH synthetase)

Cycling Strategies for Long-Term Use Cycling involves alternating periods of active treatment with rest periods