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A meta-analysis that included data from eight randomized controlled trials with a total of 327 participants with PCOS found reduced-carbohydrate diets, most lowering carbohydrate intake to 4045% of daily calories versus 5560% of calories in control diets, reduced BMI, insulin resistance, and total and LDL-cholesterol levels

Given that cytoplasmic mislocalization and aggregate formation of FUS are common in neurons in FUS-associated proteinopathies, it is likely that regulation of the FUS glutathionylation-mediated stress-mitigating mechanism by GSTOs may also underlie other ALS cases and related diseases, including FTD

(Reference Polonikov, Ivanov and Solodilova109) found that the frequencies of both allele -21A and -21AA CAT genotypes were higher among asthmatics than among healthy controls

These collective results strongly suggest a protective role for A

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doi: 10.1016/j.cj.2020.06.002