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Regarding the aetiology of the disease, it has been suggested that there is both an environmental and a genetic predisposition

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Mitchell JR, Jollow DJ, Potter WZ, Gillette JR, Brodie BB

They can promote mitochondrial biogenesis (increasing the number and function of mitochondria within cells), increase antioxidant activity, stabilize mitochondrial membranes, assist with ATP production, and modulate cell signaling and protection