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Pharmacokinetics and pharmacodynamics of high doses of pharmaceutically prepared heroin, by intravenous or by inhalation route in opioid-dependent patients

2022;44(12):e2938

doi: 10.1021/tx9702291

A decrease of up to 68.10% of the total GPx value (with mean values of 404.5939.27 U/l-hemolysed), in patients with cardiac arrhythmias and dyslipidemia and up to 73.57% (with mean values of 437.1148.58 U/l-hemolyzed), in those with arrhythmias, without dyslipidemia, revealed the existence of oxidative stress in these patients, by reducing the antioxidant level