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Secondly, the balance of GSH and GSSG is shifted toward GSSG via the GPX and GR reactions

[DOI] [Google Scholar] 53.Farooq M.A., Islam F., Yang C., Nawaz A., Athar H.-u.-R., Gill R.A., Ali B., Song W., Zhou W

E.MorrowJ

Cancer epigenetics: From mechanism to therapy

4.7 Iron Iron concentration is regulated by the hepcidin/ferroportin axis: liver hepcidin binds to tissue ferroportin, causing its internalization, blocking iron export, and therefore lowering serum concentration

Then, strong evidences from Mendelian randomization study [48], systematic review and meta-analysis [6, 9], cohort studies [7], prospective nested case-control study [8], observational studies [11] etc., indicated that elevated iron storage, ferritin, transferrin saturation, iron stores and decreased transferrin levels, is linked to a heightened risk of DM and its complication
