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Both the oxidation of nutrients in the mitochondria and the oxidation of nascent proteins in the ER generate toxic reactive oxygen species (ROS): in the mitochondria by electron leakage during oxidative phosphorylation (Murphy, 2009), and in the ER by catalysis of disulfide bond formation by ER oxidoreductase (ERO1) (Higa & Chevet, 2012)

The current treatment options for cancer vary based on the type of cancer, as well as progression, and includes chemotherapy, radiation therapy, immunotherapy, and targeted therapy

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In the Bcl-2/Caspase-3/Polymerase-1 (PARP-1) apoptosis signaling pathway, flavonoids extracted from Aspergillus flavus (FRT) inhibit apoptosis by downregulating Caspase-3 and upregulating PARP-1 and Bcl-2 protoforms, thereby achieving radiation protection (70)

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V., From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy, Nature Reviews Cancer 16, no