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Drug repurposing is best defined as the utilization of approved drugs, outside the scope of their original indication (Tran and Prasad, 2020)

This might also hint towards a role of the NACA UBA domain in assisting co-translational folding in addition to its known function in factor recruitment for signal recognition particle (SRP) or NatA/E to the ribosome 21,35

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Broader Lesson AOD-9604 serves as an instructive case in peptide pharmacology, a molecule that demonstrated intriguing biological activity but failed to achieve clinical utility