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This inhibition may result in the up-regulation of other isoforms, counteracting the intended therapeutic effects and complicating treatment outcomes

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Skeleto-muscular complaints, fatigue, insomnia, and cognitive impairments are prominent clinical manifestations of PASC, which are also common features in fibromyalgia , a disorder of the autonomic nervous system (ANS) 778

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Stinchcomb AL, Banks SL