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Accordingly, luteolin-mediated activity could potentiate the sensitivity of CRC cells to chemotherapeutic agents such as oxaliplatin, as OCTN2 is a determinant factor in oxaliplatin uptake [60]

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As a result of this neuronal loss, motor function declines progressively which then leads to impairments in respiratory function and eventually death within 25 years of diagnosis (Kiernan et al., 2011)