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Proteomics 12, 13491362

Practical studies indicate that the discontinuation rates of GLP-1RAs can reach between 20% and 50% within the first year, and patients often use significantly lower dosages compared to those tested in clinical trials [38]

The diminished levels of glutathione in the RBC and lymphocytes positively associated with increased levels of oxidative stress makers such as ROS, lipid peroxidation in SLE patients [50]
These include: receptor blocking strategies whereby putative alpha-synuclein receptors could be blocked inhibiting alpha-synuclein spread, an alpha-synuclein reduction which will decrease the amount alpha-synuclein available for aggregation and pathway disruption, the use of small molecules in order to target alpha-synuclein aggregation, immunotherapy and the increase of alpha-synuclein degradation by increasing autophagy/lysosomal flux
