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The median OS was different depending on the number of lines of palliative treatment received by the patients: 15.0 (95% CI: 6.923.1) months in patients who received only one line, 12.1 (95% CI: 10.413.8) months with two lines, 12.1 (95% CI: 8.315.8) months with three lines, and 33.6 (95% CI: 23.943.2) months with four or more lines

GBA-3::mCherry did not localize to CDF-2::GFP marked compartments in wild type (white arrowheads in insets), however it often did (white arrows within insets) in glo-1 and glo-3 mutants

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L-carnitine therapy could also be valuable in those patients who develop VPA-induced hepatotoxicity or VPA-induced hyperammonaemic encephalopathy [133]