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A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade GliomaArginine Deprivation Therapy in Recurrent High-grade Gliomas

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Neurochem Res 36(4):668676 Christie M et al (1985) Excitotoxin lesions suggest an aspartatergic projection from rat medial prefrontal cortex to ventral tegmental area

10.1016/j.aca.2018.04.006 104 YangC.DuW.YangD

Signs that warrant evaluation include: pain radiating down the arm or leg persistent numbness muscle weakness worsening symptoms over time Imaging and a physical examination help determine the underlying cause of the problem