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Characterization of oxaliplatin-induced chronic painful peripheral neuropathy in the rat and comparison with the neuropathy induced by paclitaxel
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doi: 10.1111/liv.16220 155
T.LuchiniD.MurphyM
Studies have reported that the use of bisphosphonates can delay bone metastasis in patients with breast cancer and improve overall survival (36,37)
The main toxicity provoked is acute liver damage, which is mechanistically provoked by the aberrant adduction of the toxic metabolite N-acetyl p-benzoquinone imine (NAPQI) to cysteinyl residues of key liver proteins [105]
