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Among progestin-only methods, norethindrone acetate (515 mg daily) and medroxyprogesterone (1030 mg orally daily or 150 mg intramuscularly every 3 months) have demonstrated efficacy for endometriosis-associated pain, whereas norethindrone 0.35 mg daily does not reliably induce ovulation suppression or amenorrhea and is not recommended for CPP management

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