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Only 4060% of the patients respond to first-line therapy and research for new treatment beyond current guidelines is mandatory 13

doi: 10.1016/j.bbagen.2009.03.006

While we observed differences in -KG, glutamate and proline metabolite synthesis between HIF1 and HIF2 KO NSCLC cells, both models showed increased synthesis of the TCA cycle metabolites citrate, malate, and a highly significant 3-fold increase of succinate synthesis compared to HIF WT control cells (Fig

Chino H, Yamasaki A, Ode KL, Ueda HR, Noda NN, Mizushima N

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