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10.1007/s11671-008-9174-9 205 XiaQ.ZhangY.LiZ.HouX.FengN

Cytochrome P450 enzymes mediate tamoxifen biotransformation, CYP3A4, CYP2B6, CYP2C9, CYP2C19 and CYP2D6 are the essential isoenzymes for this process

doi: 10.1038/s41416-020-01113-y 22 ChaudhryFAReimerRJKrizajDBarberDStorm-MathisenJCopenhagenDRet al

As with any research compound, it is important to review available literature, understand study findings, and evaluate data carefully

Janicka A, Szymanska-Pasternak J, Bober J

Background: Pathogenic mutations in the LRRK2 gene are believed to contribute to PD pathogenesis via elevated LRRK2 kinase activity, thereby making LRRK2 kinase inhibition a promising therapeutic option