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Competitive inhibition of carnitine/acetyl-L-carnitine reuptake by OCTN2 in kidney by the accumulating acylcarnitines (e.g

Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics

Mol.Genet.Metab 2008;94(3):287-291

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To define the effects of constitutive mTORC1 activation, several studies utilize the liver-specific knockout of TSC, leading to destabilization of the TSC complex and mTORC1 activation

These mechanisms support the administration of L-carnitine as a novel drug to reduce NAFLD
