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Development of IACS-16898 was supported by The Mark Foundation for Cancer Research

The accumulation of ROS and RNS results in the oxidation of biological molecules such as DNA, protein, and lipids, which leads to oxidative damage in cells, tissues, or organs (Zhang et al., 2020)

By promoting GH secretion, Ipamorelin can indirectly contribute to bone health, enhancing bone density and potentially reducing the risk of osteoporosis and fractures in long-term use

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[96] [119] [120] [121] [122] [123] These abnormalities have been documented both in studies using Positron emission tomography (PET) and Single-photon emission computed tomography (SPECT) scans

KI696 treatment also correspondingly increased levels of 3GC and 1DC, and this effect was diminished by erastin co-treatment (Extended Data Fig
