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Description
While this risk has not been confirmed in human epidemiological studies, patients with personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should not use orforglipron or any GLP-1 receptor agonist

Hold longer if GI effects flare

Science 369 , 731736 (2020)

the dosages causing tumors generally exceed 1,4-dioxanes metabolic saturation

Here's what I'll tell you: the skepticism is healthy, the research is real, and yes, I prescribe it in my Houston practice

doi: 10.3390/biom15020173