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10.1126/science.8316835
Emerging evidences have indicated that the activation of ferroptosis by GPX4 inhibitors (such as peptide GACNWLPLYPCPV 6 , derived by screening peptide libraries displayed on T7 phages) is increasingly recognized as a prominent therapeutic strategy for tumor suppression 7,8
Furthermore, structural comparison between the FAD and FAD_NADPH complex form indicates that the isoalloxazine ring of FAD through the hydroxyl group of Tyr174 at the re -face may be essential for controlling the NADPH binding
4 (8) e1000155
Chia-Wei Li, Academia Sinica, Taiwan Updates Copyright 2023 Zhang, Hu, Zhang, Ruan, Ma, Chen, Huang, Fan, Lin, Huang, Liao, Lu, Xu, Pi and Guo
