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doi: 10.3389/fphys.2021.660068 Received 28 January 2021 Accepted 29 March 2021 Published 27 April 2021 Volume 12 - 2021 Edited by Amanda Lochner, Stellenbosch University, South Africa Reviewed by Ben Loos, Stellenbosch University, South Africa

Given the higher complexity of the model, more clinically relevant characterization such as MRIs can also be completed

This mechanism is implicated in diseases such as rheumatoid arthritis (RA), where oxidative modifications of proteins in the synovial fluid contribute to the autoimmune response [127, 128]

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